成员简介 成员简介

最小化 最大化

 

 焦自学 

助理研究员)

 

入组时间:2015年

职称: 助理研究员

学位: 学士(化学,吉林大学)

研究方向: 高分子合成,细胞微载体

 

办公室: 主楼37

Tel.: +86-431-8526 2390

Email: aajj1983@ciac.ac.cn

 

 

教育经历

2016/9-, 长春应化所,应用化学,在职硕士

2003/09-2007/06, 吉林大学,化学系,学士

 

 科研与学术工作经历

2007/07-2015/11,长春应化所,生态室生物医用课题组,助理研究员

2015/12-至今,长春应化所,再生医学,助理研究员

科研项目:

 

1.国家自然科学基金面上项目,21074129,具有荧光和胞内控制释放性能的非病毒基因载体,2011.01 -2013.12,36万元,已结题,参与

2. 国家自然科学基金面上项目,21474104,用于间充质干细胞的高分子基因载体的设计制备和抗肿瘤治疗研究,2015.01-2018.12,88万元,在研,参与

3. 国家自然科学基金青年科学基金项目,51203153,逐级靶向高分子纳米药物载体在抗癌药物传输上的应用,2013.01-2015.12,25万元,结题,参与

4. 国家自然科学基金青年科学基金项目,51203155,嵌段聚酯增塑剂的合成及其对PLA树脂增塑和吹膜性能的研究,2013.01-2015.12,25万元,结题,参与

5. 国家自然科学基金面上项目,51273081,早期股骨头缺血坏死的骨髓细胞组织工程修复研究,2013.01-2016.12,80万元,在研,参与

6. 国家自然科学基金青年科学基金项目,51303173,多功能化药物和siRNA共载体系的制备及抗肿瘤研究,2014.01-2016.12,25万元,在研,参与

7. 国家自然科学基金青年科学基金项目,51403205,具有靶向及肿瘤细胞内特异释放性能的聚多肽胶束类基因药物共传递体系,2015.01-2017.12,25万元,在研,参与

研成果:

1、期刊论文

(1) Zixue Jiao, Jie Chen, Huayu Tian*, Xuesi Chen, Synergistic antitumor effect of cisplatin and siRNA mediated by polyethylenimine, Acta Polym. Sin., 2015, 1, 127-132.

(2) Xiuwen Guan, Yanhui Li*, Zixue Jiao, Lin Lin, Jie Chen, Zhaopei guo, Huayu Tian*, Xuesi Chen, Codelivery of antitumor drug and gene by a pH-Sensitive charge-conversion system, ACS Appl. Mater. Inter., 2015, 7, 3207-3215.

(3) Caina Xu, Huayu Tian*, Hai Sun, Zixue Jiao, Ying Zhang, Xuesi Chen, A pH sensitive co-delivery system of siRNA and doxorubicin for pulmonary administration to B16F10 metastatic lung cancer, RSC Adv., 2015, 5, 103380-103385.

(4) Jie Chen, Zixue Jiao, Lin Lin, Zhaopei Guo, Caina Xu , Yanhui Li, Huayu Tian*, Xuesi Chen, Polylysine-modified polyethylenimines as siRNA carriers for effective tumor treatment, Chinese J. Polym. Sci., 2015, 33, 830-837.

(5) Huayu Tian, Zhaopei Guo, Lin Lin, Zixue Jiao, Jie Chen, Shiqian Gao, Xiaojuan Zhu*, Xuesi Chen*, PH-responsive zwitterionic copolypeptides as charge conversional shielding system for gene carriers, J. Control. Relaese, 2014, 174, 117-125.

(6) Huayu Tian, Lin Lin, Zixue Jiao, Zhaopei Guo, Jie Chen, Shiqian Gao, Xiaojuan Zhu*, Xuesi Chen*, Polylysine-modified polyethylenimine inducing tumor apoptosis as an efficient gene carrier, J. Control. Relaese, 2013, 172, 410-418.

(7) Jie Chen, Huayu Tian*, Xuan Dong, Zhaopei Guo, Zixue Jiao, Feifan Li, Arihiro Kano, Atsushi Maruyama, Xuesi Chen, Effective tumor treatment by VEGF siRNA complexed with hydrophobic poly(amino acid)-modified polyethylenimine, Macromol. Biosci., 2013, 13, 1438-1446.

(8) Xiuwen Guan, Yanhui Li*, Zixue Jiao, Jie Chen, Zhaopei Guo, Huayu Tian*, Xuesi Chen, A pH-sensitive charge-conversion system for doxorubicin delivery, Acta Biomater., 2013, 9, 7672-7678.

(9) Lin Lin, Huayu Tian, JiaLiang Xia, Zixue Jiao, Xuan Dong, Xuesi Chen*, PEI基因载体靶向遮蔽体系的制备和表征, 中国科学, 化学, 2011, 41, 368-373.

 (10) Haitao Wu, Ting Yu, Qingsan Zhu *, Zixue Jiao, Yan Wei, Peibiao Zhang, Xuesi Chen, Preparation and osteogenesis activities of electroactive biodegradable nanocomposites PAP/op-HA/PLGA, Chem. J. Chinese U., 2011, 32, 1181-1187.

(11) 王浩,邓英杰*,焦自学,陈学思*,聚L-乳酸与聚乙二醇-b-聚L-乳酸电纺纤维中布洛芬的释放,沈阳药科大学学报,2010, 27, 686-694.

2、专利

 

 

个人风采: