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柔性透气纳米网络状电子学器件用于实时伤口状态监测和按需抗感染治疗

 

 

Adv. Funct. Mater. 2019, 1902127

 

 

柔性电子设备在能源存储、可穿戴电子传感器、人机界面、电子皮肤等方面有着巨大的潜在应用,从而引起了人们极大的兴趣。其中,具有良好柔性和生物相容性的电子学设备已经被广泛用于疾病诊断和健康监测等研究。尽管如此,能够以可控方式按需给药治疗的柔性电子学设备尚未用于实时伤口状态监测和诊疗。此外,传统的塑料基底由于舒适性欠佳、机械匹配性有待提高和透气性差等缺点,限制了其在医疗监测和按需给药治疗中的应用。因此,制备一种具有柔性、透气性且能够实时监测伤口状态,并在感染发生时进行按需给药治疗的电子学器件,对提高创面舒适性、实现创伤面的快速治疗是非常重要的。基于聚合物纳米复合材料的网络状薄膜具有高表面积、可渗透空气和液体的多孔结构、组分可控性等优点,因而是柔性的多功能型电子学器件的潜在制备材料。
    近日,北京化工大学的张立群教授和万鹏博教授报道了一种具有实时温度传感功能的柔性透气电子学器件,该设备能够在伤口部位进行伤口状态监测,提供关于感染或者炎症的信息;此外,该柔性温度传感器与无线发射机耦合,可实现实时无线温度监测。基于温敏聚合物的纳米网络状薄膜也可以组装成高效的柔性加热器,以按需触发释放载于纤维中的抗生素,从而在感染发生后及时消除伤口部位的细菌.

Flexible electronic devices have great potential applications in energy storage, wearable electronic sensors, human-machine interfaces, electronic skin, etc., which has aroused great interest. Among them, electronic devices with good flexibility and biocompatibility have been widely used in disease diagnosis and health monitoring research. Nonetheless, flexible electronics devices that can be administered on demand in a controlled manner have not been used for real-time wound condition monitoring and diagnosis. In addition, traditional plastic substrates have limited applications in medical monitoring and on-demand drug delivery due to shortcomings such as poor comfort, improved mechanical matching, and poor air permeability. Therefore, it is very important to prepare an electronic device which is flexible, breathable and capable of monitoring the wound state in real time and performing on-demand drug treatment when the infection occurs, and is effective for improving the comfort of the wound and achieving rapid treatment of the wound surface. The network-like film based on polymer nanocomposites has the advantages of high surface area, porous structure permeable to air and liquid, controllability of components, etc., and thus is a potential preparation material for flexible multifunctional electronic devices.

    Recently, Professor Zhang Liqun and Professor Wan Pengbo from Beijing University of Chemical Technology reported a flexible and ventilated electronic device with real-time temperature sensing function, which can monitor wound condition at the wound site and provide information about infection or inflammation; The flexible temperature sensor is coupled to the wireless transmitter for real-time wireless temperature monitoring. Nano-network-like films based on temperature-sensitive polymers can also be assembled into highly efficient flexible heaters to trigger the release of antibiotics contained in the fibers on demand, eliminating bacteria in the wound site in time after infection.

                                                        

 

周小松

 

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