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功能化聚醚醚酮具有增强生物相容性和成骨活性的作用

 

Materials Science & Engineering C 88 (2018) 70–78

 

   聚醚醚酮(PEEK)具有与骨弹性模量相似的弹性模量;但由于生物惰性表面化学和成骨诱导能力差,其作为骨修复材料的应用受到限制。为了解决这个问题,国家纳米科学技术中心在聚醚醚酮表面通过一步法接枝紫外线诱导的甲基丙烯酸透明质酸(MeHA)和二氧化钛(TiO2)纳米纤维。利用x射线光电子和傅立叶变换红外光谱对改性PEEK表面进行了表征,并通过测量静态接触角来评价改性程度。原子力显微镜显示,电纺TiO2接枝PEEK表面具有丰富的纳米纤维,其粗糙度可与人类的皮质骨媲美。在体外实验中,与未修饰的PEEK相比,经TiO2修饰的大鼠骨间充质干细胞具有更强的粘附、增殖和成骨分化能力。因此,经电纺TiO2MeHA表改性的PEEK具有较强的生物相容性,可作为骨科植入物和医疗器械的有效材料。

       PEEK has an elastic modulus similar to that of bone.However, due to the poor bioinert surface chemistry and osteogenic induction ability, its application as a bone repair material is limited.To solve this problem, the national center for nanoscience and technology grafted uv-induced methacrylate hyaluronic acid (MeHA) and titanium dioxide (TiO2) nanofibers on the surface of polyether ether ketone in one step.The modified PEEK surface was characterized by X-ray photoelectron and Fourier transform infrared spectroscopy, and the modified PEEK surface was evaluated by measuring the static contact Angle.Atomic force microscopy (afm) showed that electrospun TiO2 graft PEEK had abundant nanofibers on its surface, and its roughness was comparable to that of human cortical bone.In vitro experiments, tio2-modified rat bone mesenchymal stem cells showed stronger adhesion, proliferation and osteogenic differentiation compared with unmodified PEEK.Therefore, PEEK modified by electrospinning TiO2 and MeHA surface has strong biocompatibility and can be used as an effective material for orthopedic implants and medical devices.

 

(马璋玉)


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