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多孔叶叠结构颗粒缓释BMP-2在骨再生中的应用

 

 

 

 

ACS Appl. Mater. Interfaces XXXX, XXX, XXX−XXX

 

 

 

从传递系统中持续释放生物活性分子,是确保其具有长期生物活性和最大限度减少安全问题的共同策略。然而,残留的有毒试剂,有机溶剂的使用,以及传统的传输系统中复杂的制造工艺被认为是临床应用中的巨大障碍。

 

在此,Se Heang Oh教授团队利用临床上可行的材料和程序,制备了一种具有独特叶片堆叠结构并能够吸附BMP-2的多孔聚己内酯颗粒(LSS)。在这些LSS颗粒中吸附的BMP-2可持续释放至36天,为人骨膜衍生细胞的成骨分化和新骨形成提供了适宜的环境。因此,这些LSS颗粒独特的叶叠结构为有效传递各种生物活性分子(如生长因子、激素、细胞因子、多肽等)提供了一个简单但在临床上适用的平台。

 

Sustained release of bioactive molecules from delivery systems is a common strategy for ensuring their prolonged bioactivity and for minimizing safety issues. However, residual toxic reagents, the use of harsh organic solvents, and complex fabrication procedures in conventional delivery systems are considered enormous impediments toward clinical use.

Herein, professor Se Heang Oh's team describe bone morphogenetic protein-2 (BMP-2)-immobilized porous polycaprolactone particles with unique leaf-stacked structures (LSS particles) prepared using clinically feasible materials and procedures. The BMP-2 immobilized in these LSS particles is continuously released up to 36 days to provide an appropriate environment for osteogenic differentiation of human periosteum-derived cells and new bone formation. Thus, the leaf-stacked structures of these LSS particles provide a simple but clinically applicable platform for effectively delivering a variety of bioactive molecules, such as growth factors, hormones, cytokines, peptides, etc.

 

 


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