最近福建师范大学王正超团队成功合成了CS@ZnAlg微球。通过SEM, FT-IR, XPS等表征验证了该材料的合成，以及通过鼠肝脏裂伤，尾部断裂实验很好的验证了该CS@ZnAlg微球良好的止血效果。
Quick hemostats for non-lethal massive traumatic bleeding in battleﬁeld and civilian accidents are important for reducing mortality and medical costs. Chitosan (CS) has been widely used as a clinic hemostat. To enhance its hemostatic eﬃciency, Zn²⁺ in the form of zinc alginate (ZnAlg) was introduced to CS to make porous CS@ZnAlg microspheres. The composite microspheres had an outer and internal interconnected porous structure. Their size, surface area, and water absorption ratio Compared to the neat chitosan microspheres, the CS@ZnAlg microspheres showed shorter onset of clot formation, much faster in vitro and in vivo whole blood clotting, bigger clot, less blood loss, and shorter hemostatic time in the rat liver laceration and tail amputation models. The synergetic hemostatic eﬀects from (1) the electrostatic attraction between chitosan component and red blood cells, (2) the activation of coagulation factor XII by Zn²⁺ of zinc alginate component, and (3) physical blocking by microsphere matrix, contributed to the enhanced hemostatic performance of CS@ZnAlg microspheres.
Recently, Fujian Provincial Key Laboratory of Polymer Materials, Fujian Normal University Zhengchao Wang team successfully synthesized CS@ZnAlg microsphere the synthesized of this material was verified by SEM，FTIR，XPS and other characterization, as well as the rat liver lacerated and tail fracture experiment was good to verify the hemostatic effect of the CS@ZnAlg microsphere.