1. Biomaterials and Biomimetic Materials (生物医用仿生材料)

The works will based on the demands of biomedical application, and the strategies to biomimic the ingredients, structures and fuctions of natural tissues. i. To biomimetically design, synthesize or prepare novel bioactive macromolecules or polymers which can accelerate cell growth, differetiation and tissue regeneration. ii.In situ polymerization or grafting of these bioactive macromolecules on  functional inorganic particles (i.e, hydroxyapatites) will be employed to develop new nanocomposites or nanomaterials with  biomimetic compositions and structures for regenerative medicine.

(从医学应用的需求出发,根据天然组织的成分组成、结构和功能,采用生物合成(基因工程)或化学合成(接枝或共聚)方法,设计、合成和仿生制备有利于细胞生长分化和组织再生的生物活性大分子或共聚物;并采用原位聚合或接枝改性方法对无机功能粒子进行表面修饰改性,开发材料复合的新技术和新工艺,制备具有仿生组分和结构的再生医学相关新材料和新产品。)

 

 

2. Tissue/organ scaffolds (组织与器官支架)

Besides its biocompatibility, biodegradation, and bioactivity, the shape, microstructure, mechanical properties and surface properties of a new material  will also be closely related to its application in tissue engineering or regenerative medicine. i. A series of processing techniques, including electrospinning, centrifugal spinning, particulate leaching, gas foaming, freeze-drying, and 3D printing, have been developed to prepare biological scaffolds of tissue engineering. ii. Surface modification of the scaffolds with physical, chemical or biological methods will be explored. iii. The factors and mechanisms related to tissue regeneration will be studied. Furthermore, some implantable medical devices have been designed and developed for repair or replacement of damaged tissues or organs, such as bone, cartilage or skin, et al. The new technologies of injectable materials and personalized medicine will also be explored.

(生物医用材料在组织工程与再生医学中的应用,除与材料的生物相容性、生物降解性和生物活性有关,还与材料的形状、结构、机械性能和表面性质等因素密切相关。采用静电纺丝、离心纺丝、粒子沥滤、气体发泡、相分离和3D打印等方法,开发支架或器件的加工成型工艺和物理、化学或生物表面修饰技术,研究影响组织再生的相关因素和机制,制备可用于骨、软骨、皮肤等不同组织/器官修复或替代的植入型器械,探索可注射和个性化医疗新技术。)

3. Electric/Electromagnetic signals and its Biological response(电/磁信号与生物应答)

Organ growth or tissue regeneration are usually resulted from the changes of cell activities, including cell growth, spreading, migration, differentiation and the secretion of excelluar matrices (ECM).  Although chemical signals are the main way  of information transmission between cells and cells, electrical signal in cells or between cell and cell is also important factors for guide cell activity. Thus we design and synthesize a series of conductive, electroactive or Electromagnetic responsed biodegradable polymers or composites. Their effects on cell activities and functions of stem cells, and the disciplanation or molecular mechanism of stem cell's directional growth and differentiation stimulated by electric/electromagnetic signals will be explored. The regenerative technologies of nerve, cardiac muscle or bone with biophysical instruments will be developed.

(器官形成与组织再生通常表现为细胞的生长、迁移、分化和基质分泌等诸多行为改变,虽然化学信号是细胞与细胞之间信息传递的主要形式,但胞内和胞间的电信号传导是影响细胞行为的重要因素。我们的兴趣是通过设计合成具有导电性、电活性或电磁响应性的生物降解高分子及杂化材料,研究其对干细胞行为和功能的影响,揭示生物电/磁信号影响干细胞定向生长分化的规律和分子机制,探索生物物理技术在神经、心肌和骨骼等组织再生中的应用。)