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RSC Adv., 2016,6, 2131-2134, DOI: 10.1039/C5RA25142G, Communication

Improved cellular infiltration into 3D interconnected microchannel scaffolds formed by using melt-spun sacrificial microfibers

Zongliang Wang,ac Tianlin Gao,b Liguo Cui,a Yu Wang,a Peibiao Zhang*a and Xuesi Chen a


* Corresponding authors

a Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
E-mail: zhangpb@ciac.ac.cn
Fax: +86 431 85262058
Tel: +86 431 85262058

b School of Public Health, Jilin University, Changchun, P. R. China

c University of Chinese Academy of Sciences, Beijing 100039, P. R. China


Abstract


We report a novel fabrication method using melt-spun sacrificial microfibers to make 3D interconnected microchannel scaffolds for improved cellular infiltration. The uniformly distributed cells in the highly porous microchannel scaffold maintained high cellular viability and glycosaminoglycan secretion indicating the good interconnectivity facilitates the smooth delivery of cells throughout the scaffold and allows sufficient oxygen and nutrient mass transport into the scaffold.
 

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