医用级原料-聚乳酸-聚羟基乙酸共聚物(PLGA)

又名聚丙交酯-乙交酯

英文名Poly(lactide-co-glycolide) (PLGA)

分子结构式

外观性状：粉体、块状、颗粒和纤维

材料特点：PLGA是PLA和PGA的共聚物，是脂肪族聚酯中最为常用的一种共聚物，具有生物相容性和生物降解性。LA和GA的比例一般为90:10，80:20，70:30等，分子量5-15万可调，也可根据客户需求定制。由于PLA和PGA的降解速率不同，通过调节两者共聚比例和分子量，能够获得不同降解时间、不同力学性能的可降解高分子材料，适用于组织工程支架、器官支架、软硬组织修复、美容填充、药物载体等。

保存条件：长期保存于-20 oC冷冻，真空包装条件下。短期可保存于真空干燥器。

使用方法及案例：

一、骨组织工程支架

1、溶液浇铸/粒子沥滤法

In vivo mineralization and osteogenesis of nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with poly(l-lactide). Biomaterials, 2009, 30:58-70.
Peibiao Zhang, Zhongkui Hong, Ting Yu, Xuesi Chen, Xiabin Jing.

RGD-conjugated copolymer incorporated into composite of poly(lactide-co-glycotide) and poly(l-lactide)-grafted nanohydroxyapatite for bone tissue engineering. Biomacromolecules, 2011, 12(7):2667-2680.
PeibiaoZhang, Haitao Wu, Han Wu, ZhongwenLu, Chao Deng, Zhongkui Hong, XiabinJing, XuesiChen

In vivo degradation behavior of porous composite scaffolds of poly(lactide-co-glycolide) and nano-hydroxyapatite surface grafted with poly(L-lactide). Chinese Journal of Polymer Science, 2014, 32(6):805-816.
Yu-feng Tang, Jian-guo Liu, Zong-liang Wang, Yu Wang, Li-guo Cui, Pei-biao Zhang*, Xue-si Chen.

Tissue-engineered composite scaffold of poly(lactide-co-glycolide) and hydroxyapatite nanoparticles seeded with autologous mesenchymal stem cell (MSCs) for bone regeneration. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 2017, 18(11):963-976.
Bing ZHANG, Pei-biao ZHANG, Zong-liang WANG, Han WU.

2、熔融成型/粒子沥滤法

The Nano-Composite Scaffold of Poly(lactide-co-glycolide) andHydroxyapatite Surface-Grafted with L-lactic Acid Oligomer for Bone Repair. Acta Biomaterialia, 2009, 5:2680-2692.
Yang Cui, Yi Liu, Yi Cui, Xiabin Jing, Peibiao Zhang*, XuesiChen.

Enhanced in vitro mineralization and in vivo osteogenesis of composite scaffolds through controlled surface grafting of L-lactic acid oligomer on nano-hydroxyapatite. Biomacromolecules, 2016, 17(3):818-829.
Wang, Zongliang, Xu, Yang, Wang, Yu , Ito, Yoshihiro, Zhang, Peibiao*, Chen, Xuesi

3、单溶剂冷冻成型法

Preparation ofPorous Nanocomposite Scaffolds with Honeycomb Monolith Structure by OnePhase Solution Freeze-Drying Method. Chinese Journal of Polymer Science, 2011, 29(2):215-224.
Yang Xu, Duo Zhang**, Zong-liang Wang, Zhan-tuanGao, Pei-biao Zhang* and Xue-si Chen.

4、可注射原位固化成型法

An injectable hydroxyapatite/poly(lactide-co-glycolide) composite reinforced by micro/nano-hybrid poly(glycolide) fibers for bone repair. Materials Science and Engineering: C, 2017, 80:326-334.
Yuhang Zhu,Zongliang Wang,Hongli Zhou,Linlong Lib,Qingsan Zhu*,Peibiao Zhang*.

In vitro degradation behavior of hydroxyapatite/poly(lactide-co-glycolide) composite reinforced by micro/nano-hybrid poly(glycolide) fibers for bone repair. Journal of Materials Chemistry B, 2017, 5(44):8695-8706.
Yuhang Zhu, Zongliang Wang*, Linlong Li, Daqian Gao, Qinli Xu, Qingsan Zhu*, Peibiao Zhang*.

5、静电纺丝载药纤维毡

Methylsulfonylmethane-loaded electrospun poly(lactide-coglycolide) mats for cartilage tissue engineering. RSC Advances, 2015, 5:96725-32.
Zongliang Wang, Yu Wang, Peibiao Zhang*, and Xuesi Chen.

6、熔融旋碟纺丝纤维

A Novel Nano/Micro-Fibrous Scaffold by Melt-Spinning Method for Bone Tissue Engineering. Journal of Bionic Engineering, 2015, 12(1):117-128.
Liguo Cui, Ning Zhang, Weiwei Cui, Peibiao Zhang, Xuesi Chen.

Improved cellular infiltration into 3D interconnected microchannel scaffolds formed by using melt-spun sacrificial microfibers. RSC Advances, 2016, 6:2131-33.
Zongliang Wang, Tianlin Gao, Liguo Cui, Yu Wang, Peibiao Zhang* and Xuesi Chen.

7、溶剂交换3D打印成型法

3D-printing of solvent exchange deposition modeling (SEDM) for a bilayered flexible skin substitute of poly (lactide-co-glycolide) with bioorthogonally engineered EGF. Materials Science & Engineering C, 2020, 112:110942.
Daqian Gao, Zongliang Wang, Zhenxu Wu, Xincui Shi, Min Guo, Yu Wang*, Zhenhua Gao*, and Peibiao Zhang*, Yoshihiro Ito.

8、微流控二流法制备微载体(微球)

Assessment of nano-Hydroxyapatite and Poly (Lactide-co-Glycolide) nanocomposite microspheres fabricated by novel airflow shearing technique for in vivo bone repair.Materials Science and Engineering: C,2021, 128: 112299
Song Wenzhi*, Wang Dezhou, Guo Min, Han Chunyu, Zhao Lanlan, Zhang Peibiao*.

二、涂膜法研究成骨活性

聚乳酸接枝改性纳米生物玻璃/PLGA复合材料的制备、表面性质及生物活性. 高等学校化学学, 2009, 30(5):1018-1023.
董树君, 于婷, 魏俊超, 景遐斌, 周延民, 章培标*, 陈学思.

改性纳米羟基磷灰石/PLGA复合材料的制备及生物活性. 高等学校化学学, 2009, 30(7):1439-1444.
于婷, 刘娅, 王宇, 景遐斌, 章培标*, 陈学思.

脉冲电刺激对改性纳米羟基磷灰石/聚丙交酯-乙交酯复合材料表面成骨细胞增殖及成骨活性的影响[J]. 中国组织工程研究与临床康复, 2009, 13(16):3065-3069.
于婷, 刘娅, 邬海涛, 崔巍巍, 王宇, 景遐斌, 章培标*, 陈学思.

电活性可生物降解纳米复合材料PAP/op-HA/PLGA的制备及成骨活性. 高等学校化学学, 2011, 32(5):1181-1187.
邬海涛, 于婷, 朱庆三, 焦自学, 危岩, 章培标*, 陈学思.

Photo-immobilization of Bone Morphogenic Protein 2 on PLGA/HA Nanocomposite to Enhance the Osteogenesis of Adipose-Derived Stem Cells. RSC Adv., 2016, 6:20202-20210.
Tianlin Gao, Weiwei Cui, Zongliang Wang, Yu Wang, Ya Liu, Ponnurengam Sivakumar Malliappan, Yoshihiro Ito and Peibiao Zhang*.

Improved Cell Adhesion and Osteogenesis of op-HA/PLGA Composite by Poly(dopamine)-Assisted Immobilization of Collagen Mimetic Peptide and Osteogenic Growth Peptide. ACS Applied Materials & Interfaces, 2016, 8(40):26559-69.
Wang, Zongliang; Chen, Li; Wang, Yu; Chen, Xuesi; Zhang, Peibiao*.

三、功能材料开发

1、载IGF-1微载体用于骨再生

Biodegradable Microcarriers of Poly(Lactide-co-Glycolide) and Nano-Hydroxyapatite Decorated with IGF-1 via Polydopamine Coating for Enhancing Cell Proliferation and Osteogenic Differentiation. Macromol Biosci., 2015, 15(8):1070-80.
Tianlin Gao, Ning Zhang, Zongliang Wang, Yu Wang, Ya Liu, Yoshihiro Ito, Peibiao Zhang*.

DOPA-derived electroactive copolymer and IGF-1 immobilized poly(lactic-co-glycolic acid)/hydroxyapatite biodegradable microspheres for synergistic bone repair.Chemical Engineering Journal, 2021, 416: 129129
Huanhuan Yan, Zongliang Wang, Linlong Li, Xincui Shi, Erna Jia, Qingming Ji, Yu Wang*, Yoshihiro Ito, Yen Wei, Peibiao Zhang*.

2、可MRI示踪材料

In vivo MRI and X-ray bifunctional imaging of polymeric composite supplemented with GdPO4*H2O nanobundles for tracing bone implant and bone regeneration. Advanced Healthcare Materials, 2016, 5(17):2182-90.
Jing Huang; Zhongwen Lv; Yu Wang; Zongliang Wang; Tianlin Gao; Ning Zhang; Min Guo; Haifeng Zou*; Peibiao Zhang*.

Incorporation of Gadolinium Oxide and Gadolinium Oxysulfide Microspheres: MRI/CT Monitoring and Promotion of Osteogenic/Chondrogenic Differentiation for Bone Implants.ChemNanoMat,2020,6(12):1819-1832.
Jing Huang, Zhaoyun Tang, Min Guo, Yu Wang, Zongliang Wang, Zhenxu Wu, Peibiao Zhang*.

Biodegradable GdPO4·H2O/PLGA microcarriers for stem cell delivery and non-invasive MRI translocation tracing[J]. Journal of Materials Science, 2022, 57(28):13632-13646.
Wenhao Zhu，Zhenxu Wu，Peng Wang，Tianyi Liu，Min Guo，Jiansong Ji，Mingfeng He*，Haifeng Wang，Peibiao Zhang*

3. 载DOPA-IGF-1用于神经再生

A Novel Approach via Surface Modification of Degradable Polymers With Adhesive DOPA-IGF-1 for Neural Tissue Engineering. J Pharm Sci., 2019, 108(1):551-562.
Yi Zhang, Zongliang Wang, Yu Wang, Linlong Li, Zhenxu Wu, Yoshihiro Ito, Xiaoyu Yang*, Peibiao Zhang

Nerve implants with bioactive interfaces enhance neurite outgrowth and nerve regeneration in vivo. Colloids and Surfaces B: Biointerfaces, 2022, 218: 112731.
Zongliang Wang, Yi Zhang, Liqiang Wang, Yoshihiro Ito, Gang Li, Peibiao Zhang*.

4、 DOPA-NGF微载体用于神经再生

Bioorthogonal DOPA-NGF activated tissue engineering microunits for recovery from traumatic brain injury by microenvironment regulation. Acta Biomaterialia, 2022, 150: 67-82.
Wenhao Zhu, Li Chen, Zhenxu Wu, Wenzhong Li, Xiaolong Liu, Yu Wang, Min Guo, Yoshihiro Ito, Liqiang Wang, Peibiao Zhang*, Haifeng Wang*.

5、电活性导电复合材料

电活性和生物活性多巴-胰岛素样生长因子-1@聚(乙交酯-丙交酯)/聚(3-己基噻吩)静电纺丝纤维的制备及神经组织工程应用.应用化学,2019, 36 (9): 1003-1014.
张守燕, 胡江磊, 史新翠, 章培标, 伊藤嘉浩

Electroactive Composite of FeCl3 -Doped P3HT/PLGA with Adjustable Electrical Conductivity for Potential Application in Neural Tissue Engineering.Macromol Biosci. 2019,19(10):e1900147.
Shouyan Zhang, Huanhuan Yan, Jui‐Ming Yeh, Xincui Shi*, Peibiao Zhang*.

6、磁响应性智能材料

Synergistic osteogenesis promoted by magnetically actuated nano-mechanical stimuli. Nanoscale, 2019, 11, 23423-2343.
Hao, Lili; Li, Linlong; Wang, Peng; Wang, Zongliang; Shi, Xincui; Guo, Min ; Zhang, Peibiao*.

Spatiotemporal magnetocaloric microenvironment for guiding the fate of biodegradable polymer implants. Advanced Functional Materials, 2021, 31(15): 2009661.
L. Hao, J. Li, P. Wang, Z. Wang, Z. Wu,Y. Wang, Z. Jiao, M. Guo,* T. Shi,Q. Wang, Y. Ito, Y. Wei,P. Zhang*.

7、电和磁共响应性智能材料

The electric and magnetic responsive nanocomposite of GdPO4·H2O/P3HT/PLGA with electrical stimulation for synergistically enhancing the proliferation and differentiation of pre-osteoblast.New Journal of Chemistry,2019,43:17315-17326
Yan, Huanhuan; Li, Linlong; Wang, Yu; Huang, Jing; Wang, Zongliang; Shi, Xincui; Zhang, Peibiao*.

8、可载干细胞PVA  /PLGA双层敷料

Stem Cell Seeded and Silver Nanoparticles Loaded Bilayer PLGA/PVA Dressings for Wound Healing.Macromolecular Bioscience, 2020,20(10):e2000141
Tianlin Gao, Chunyan Tian, Zepeng Ma, Zunyan Chu, Zongliang Wang, Peibiao Zhang.

9、压电性双示踪智能材料

Gadolinium-doped BTO Functionalized Nanocomposites with Enhanced Dual-imaging of MRI and X-Ray to Simulate the Electrical Properties of Bone”. ACS Applied Materials & Interfaces, 2020, 12(44): 49464-49479
Peng Wang, Lili Hao, Zongliang Wang, Yu Wang, Min Guo*, Peibiao Zhang