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Mater Sci Eng C Mater Biol Appl. 2017 Nov 1;80:326-334. doi: 10.1016/j.msec.2017.04.121. Epub 2017 Apr 26.

An injectable hydroxyapatite/poly(lactide-co-glycolide) composite reinforced by micro/nano-hybrid poly(glycolide) fibers for bone repair.
 
Zhu Y 1, Wang Z 2, Zhou H 1, Li L 3, Zhu Q 4, Zhang P 5.
 
Author information
1 Department of Orthopedics, China-Japan Union Hospital, Jilin University, 126 Xiantai Street, Changchun 130033, PR China;
2 Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, PR China.
3 Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, PR China.; University of Science and Technology of China, 96 Jinzhai Road, Hefei 230026, PR China.
4 Department of Orthopedics, China-Japan Union Hospital, Jilin University, 126 Xiantai Street, Changchun 130033, PR China. Electronic address: zhuqs@jlu.edu.cn.5Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, PR China.. Electronic address: zhangpb@ciac.ac.cn.

Abstract
Porous nanocomposite of hydroxyapatite/poly(lactide-co-glycolide) (HA/PLGA) is conventionally used in bone tissue engineering but seldom in load-bearing orthopedic applications due to poor mechanical property. This study aimed to fabricate an injectable ternary composite by incorporating different contents of poly(glycolide) (PGA) fibers (0, 30, 50 and 70wt%) into the nanocomposite HA/PLGA matrix as reinforcing fillers for bone tissue repair. The fibers were obtained from melt-spinning and fiber diameter ranged from 70nm to 191μm. The injectability, mechanical strength, solidification rate and cytotoxicity of injectable composites were characterized. All composites achieved the acceptable injectability under an injection force of 100N. The mechanical properties of composites were gradually enhanced by increasing PGA fiber contents. The compression strength of composite with 70wt% content of PGA fibers was up to 31.1MPa, which was four times stronger than that of composite without PGA fibers. In the solidification rate analysis, the compression strength of composites with 50 or 70wt% PGA fibers in immersion time of only 45min was similar to that of composite without fibers in immersion time of 4-5h. The MTT test showed that exceeding 70% cells could survive in the fourfold dilution of extract, and its cytotoxicity focused on the first 4h after immersing. This study have revealed that the PGA fiber-reinforced HA/PLGA composite is a promising candidate for orthopedic applications.
Copyright © 2017. Published by Elsevier B.V.
Fig. 2
Fig. 2. The schematic illustration of preparation of injectable ternary composite pastes and their application in bone defect repair.

PMID: 28866171 DOI: 10.1016/j.msec.2017.04.121

Highlights

•An injectable PGA fiber-reinforced HA/PLGA composite is fabricated.
•The micro/nano-hybrid PGA fibers are prepared by melt-spinning.
•The mechanics of obtained composites are significantly enhanced by adding PGA fibers.
•The composite is a promising candidate for bone repair by minimally invasive way.
 
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