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Journal of Applied Polymer Science,Volume 134, Issue 37, October 05, 2017:45271 

Biomimetic porous collagen/hydroxyapatite scaffold for bone tissue engineering
 
Li Chen, Zhenxu Wu, Yulai Zhou, Linlong Li, Yu Wang, Zongliang Wang, Yue Chen and Peibiao Zhang
 
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Abstract
Bone defect and osteochondral injury frequently occur due to diseases or traumatism and bring a crucial challenge in orthopedics. The hybrid scaffold has shown promise as a potential strategy for the treatment of such defects. In this study, a novel biomimetic porous collagen (Col)/hydroxyapatite (HA) scaffold was fabricated through assembling layers of Col containing gradual amount of HA under the assistance of “iterative layering” freeze-drying process. The scaffold presents a double gradient of highly interconnected porosity and HA content from top to bottom, mimicking the inherent physiological structure of bone. Owing to the biomimetic structure and component, significant increase of cell proliferation, alkaline phosphatase activity, and osteogenic differentiation in vitro was observed, illustrating potential application of the excellent Col/HA scaffold as a promising strategy for bone tissue engineering. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45271
 
Figure 1.

Figure 1.

General appearance of the multi-layered Col-HA composite scaffold (a,b). ESEM micrographs of the multi-layered Col-HA composite scaffold (c, vertical section), the upper layer with the HA content of 30% (d), the intermediate layer with the HA content of 50% (e), and the lower layer with the HA content of 70% (f). [Color figure can be viewed at wileyonlinelibrary.com]

 
 
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Version of Record online : 5 JUN 2017, DOI: 10.1002/app.45271
 
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