Chemical Engineering Journal 424 (2021) 130429

压疮是皮肤和底层组织的局部损伤区域，给患者和医疗系统带来了重大负担。虽然ADSCs和PRP在治疗上是有效的，但它们在体内停留的时间很短。天然高分子水凝胶具有多功能，在促进慢性创面愈合方面最具吸引力。因此，需要开发一种新的方法来制备ADSCs和PRP的控释水凝胶，以达到最佳的治疗效果。

近日，广州医科大学第二附属医院转化医学中心、暨南大学生物医学工程系和广东省医学科学院广东省人民医院广东省心血管病研究所的三位教授以甲基丙烯酸酯明胶(GelMA)和甲基丙烯酸化丝素(SFMA)为细胞和生长因子载体，研制脂肪干细胞(ADSCs)和富血小板血浆(PRP)水凝胶系统，用于治疗压疮。研究证明GelMA/SFMA/PRP/ADSCs水凝胶具有持续释放ADSCs和PRP的能力，在促进慢性创面愈合方面具有巨大潜力，特别是在压疮皮肤中。

Pressure ulcers are areas of localized damage to the skin and underlying tissue, which impose a major burden to patients and medical systems. Although ADSCs and PRP are therapeutically effective, they stay in the body for a short time. Natural polymer hydrogels are multifunctional and are the most attractive in promoting the healing of chronic wounds. Therefore, it is necessary to develop a new method to prepare controlled-release hydrogels of ADSCs and PRP to achieve the best therapeutic effect.

Recently, three professors from the Translational Medicine Center of the Second Affiliated Hospital of Guangzhou Medical University, the Department of Biomedical Engineering of Jinan University, and the Guangdong Provincial Institute of Cardiovascular Diseases, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences， they developed adipose-derived stem cells (ADSCs) and platelet-rich plasma (PRP) loaded hydrogel system based on methacrylate gelatin (GelMA) and methacrylated silk fibroin (SFMA) as cell and growth factors delivery vehicles for the treatment of pressure ulcers. Overall, this results suggest that GelMA/SFMA/ PRP/ADSCs hydrogel with the sustainable release ability of ADSCs and PRP will possess great potential for promoting the chronic wound healing, especially in pressure ulcers skin.

贠智赫