Adv Healthc Mater. 2016 Jul 6. doi: 10.1002/adhm.201600249.
In Vivo MRI and X-Ray Bifunctional Imaging of Polymeric Composite Supplemented with GdPO4 ·H2 O Nanobundles for Tracing Bone Implant and Bone Regeneration.
Huang J 1,2, Lv Z3, Wang Y 2, Wang Z 2, Gao T 2,4, Zhang N 5, Guo M 2, Zou H 1, Zhang P 2.
1College of Chemistry, Jilin University, Changchun, 130012, P. R. China.
2Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
3China-Japan Union Hospital, Jilin University, Changchun, 130021, P. R. China.
4School of Public Health, Jilin University, Changchun, 130021, P. R. China.
5Department of Foot and Ankle Surgery, The Second Hospital of Shandong University, Jinan, 250000, P. R. China.
Homogeneous and monodisperse GdPO4 ·H2 O nanobundles are successfully synthesized via a solvothermal method. Then, GdPO4 ·H2 O are incorporated into the composite of hydroxyapatite and poly(lactic-co-glycolic acid) to obtain a biodegradable and traceable bone implant. After implanted, the GdPO4 ·H2 O/HA/PLGA implant and the newly formed bone can be easily traced and observed through the combination of magnetic resonance imaging and X-ray imaging.
MR imaging; bone repair; gadolinium phosphate; hydroxyapatite; poly(lactic-co-glycolic acid); radiography