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日光驱动抗菌和抗病毒纳米纤维膜的生物应用
Si et al., Sci. Adv. 2018;4: eaar5931
禽流感，细菌和病毒的传播严重威胁人们健康，新发传染病的爆发对全球公共卫生安全也造成了一定的威胁，因此具有抗菌性能的材料对阻止细菌和病毒的传播具有积极的作用。传统的防护材料，有些不具有抗菌性能，有些在材料中加入抗菌剂（三氯，抗菌肽，壳聚糖，纳米银）达到抗菌的目的，但这种抗菌性能会随着抗菌剂的减少抗菌性能下降，有些材料通过加入光敏剂（盐胺）使材料具有较稳定的抗菌性能，但所需要的光为紫外光且昏暗和黑暗环境下抗菌性能减弱。因此需要一种杀菌持久性、可重用且适合黑暗下使用的抗菌材料。 东华大学纺织学院重点实验室与美国加州大学共同开发了一种日光可驱动的且可循环使用的抗菌和抗病毒的纳米纤维膜用于生物防护材料。结果表明通过电纺纳米纤维和日光活性光敏剂的结合。光活性纳米纤维膜可在光照射下储存生物杀灭活性，并可在较暗或较暗的条件下释放活性氧，具有生物杀灭功能。纳米纤维膜具有生成活性氧快、活性储存容易、长期耐用、生物杀灭效果好等特点，无论在光照条件下还是在黑暗条件下，都能快速有效地杀灭细菌和病毒。 The spread of avian influenza, bacteria and viruses seriously threatens people’s health, and the outbreak of new emerging infectious diseases also poses a certain threat to global public health security. Therefore, materials with antibacterial properties have a positive effect on preventing the spread of bacteria and viruses.Traditional protective materials, some do not have antibacterial properties. some antibacterial agents were added into material, such as triclosan, peptide, chitosan, and silver nanoparticles, to prevent bacteria and viruses, but the antibacterial performance will be reduced with antibacterial agents reduce. some photosensitizer were added into materials to make materials have stable antibacterial performance, but the light of the need was UV light. Therefore, an antibacterial material that is durable, reusable and suitable for use in the dark is needed. The key laboratory of textile college of donghua university and the university of California have jointly developed a sunlight-driven, recyclable antimicrobial and antiviral nanofiber membrane for biological protection materials. The results show that the electrospun nanofibers are combined with the active photosensitizer of sunlight. Photoactive nanofiber membrane can store biocide activity under light irradiation and release reactive oxygen species under dark or dark conditions. Nano-fiber membrane has the character of rapid generation of reactive oxygen species, easy storage, long-term durability and good biological killing effect. It can kill bacteria and viruses rapidly and effectively under both light and dark conditions。
吕彩莉
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