美国480生物医药公司的MariaPalasis团队与哈佛大学及麻省理工学院的研究人员合作，共同在Nature Materials上发表了一篇标题为“The development of bioresorbable composite polymeric implants with high mechanical strength”的文章。
Maria Palasis, a team of 480 biomedical companies in the United States, works with researchers from Harvard University and the Massachusetts institute of technology common in Nature Materials on published an article entitled “The development of bioresorbable comosite polymeric implants with high mechanical strength”. In this work, they developed a scaffold from variants of poly(glycolic) acid which were braided and coated with an elastomer of poly(glycolide-co-caprolactone) and crosslinked. The coating of the scaffold with the elastomer led to higher mechanical strength in terms of compression, expansion and elasticity compared to braids without the elastomer coating. These composite scaffolds were found to have expansion properties similar to metallic stents, utilizing materials which are typically much weaker than metal. they optimized the mechanical properties of the implant by tuning the elastomer branching structure, crosslink density, and molecular weight. The scaffolds were shown to be highly resorbable following implantation in a porcine femoral artery. Biocompatibility was studied in vivo in an ovine model by implanting the scaffolds into femoral arteries. The scaffolds were able to support an expanded open lumen over 12 months in vivo and also fully resorbed by 18 months in the ovine model.