ACS Nano 2019, 13, 13581-13594

        随着人口老龄化的加剧，市场上对可以加速骨再生的植入体的材料的需求越来越大。最近，湖北大学材料科学与工程学院吴水林教授课题组，使用硫化铋/羟基磷灰石制备了一种用于骨修复的新型植入材料，其可产生稳定的光电响应微环境。当硫酸铋与羟基磷灰石结合时，硫酸铋吸收光子，然后产生光电子和电子空穴。光电子转移到HAp中的磷酸盐中，减少了光电子与空穴的结合。因此，BS/HAp膜的光催化能力增强，光电流增加。此外，当光电子转移到间充质干细胞的细胞膜上时，与钠有关的基因表达发生了变化。钠在细胞内和细胞外位置的浓度改变，导致膜电位的变化。这种电位差导致Ca²⁺从间充质干细胞外流入细胞内线粒体。不断增加的Ca²⁺进一步上调FDE1，并最终进入细胞核调节TCF/LEF。最后，DNA调控与成骨分化相关的下游基因，达到骨修复的效果。

         With an aging population, the market demand and research interest in arti implants have increased Recently, Professor Wu Shuilin’s group from the School of Materials Science and Engineering, Hubei University create a fast and repeatable photoelectric-responsive microenvironment around an implant using a bismuth sulfide/hydroxyapatite (BS/HAp) film. When BS is combined with HAp, the BS absorbs photons and then produces photoelectrons and electron-hole pairs. The photoelectrons are transferred to the phosphate in HAp, which decreases the combination of photogenerated electrons and holes. As a result, the photocatalytic capability of the BS/HAp film is enhanced and the photocurrent is increased. Furthermore, when the photogenerated electrons transfer to the membrane of MSCs, sodium-related gene expression changed. The concentration of sodium in intracellular and extracellular locations alters, resulting in a change in the membrane potential. This potential difference causes the Ca²⁺ inflow from the outside of the MSCs to the intracellular mitochondria. The increasing Ca²⁺ further upregulates FDE1 and ultimately enters the cell nucleus to regulate the TCF/LEF. Finally, DNA regulates the downstream genes related with osteogenic differentiation.

doi:10.1021/acsnano.9b08115

 

                                                               王鹏