商用骨黏合剂的有效性是众所周知的,但其作用由于细胞生长能力弱而受影响。大孔隙策略，特别是具有生物活性的大孔隙，具有广阔的应用前景。有相当大的希望来规避这个问题，从而促进骨折愈合。这是一类含有生物活性玻璃的大孔内嵌骨粘合剂的开发，其能够促进骨源性间充质基质细胞迁移到黏附层并分化为骨细胞。将具有生物活性玻璃的颗粒包裹为成孔剂在骨黏合剂中整合是这一方法的关键。我们观察到，在小鼠颅骨上，粘接剂的快速粘接和骨再生效率高，这两者对于临床应用和个性化手术程序都是至关重要的。这项工作代表了设计具有高细胞生长功效的生物材料的一般策略。

The effectiveness of commercial bone adhesives is known to be hampered by the weak efficacy of cell ingrowth. The strategy of macroporeforming, especially bioactive macropores, holds considerable promise to circumvent this problem, thereby promoting fracture healing. Herein, a class of bioactive glass-involved macropore-embedded bone
adhesives is developed, which is capable of facilitating the migration of bone-derived mesenchymal stromal cells into the adhesive layer and differentiation into osteocytes. The integration of bioactive glass-particleencapsulated porogens in the bone adhesives is key to this approach. A robust instant bonding on the bone adhesive and a high efficiency of bone regeneration on a mouse skull are observed, both of which are vital for clinical applications and personalized surgical procedures. This work represents a general strategy to design biomaterials with high cellingrowth efficacy.

DOI：10.1002/adma.201907491

王成龙