Adv. Healthcare Mater. 2018, 1701086
Wounding with medical gauze is the most common and conventional hemostasis method. The mechanism is that the gauze absorbs water in the blood and concentrates blood cells and coagulation factors, thus promoting blood coagulation.However, the problem of excessive absorption of blood by traditional medical gauze has been neglected for a long time, which often leads to excessive bleeding in the wound. In severe cases, patients will still die due to excessive blood loss.The traditional medical gauze uses pressure to compress the blood vessels of the wound when dressing the wound, so that the blood flow rate of the wound slows down, but the traditional gauze will absorb a large amount of blood.
In collaboration with Professor Shao Longquan of Southern Medical University, Ning Zhao and Jian Xu from the Laboratory of Polymer Physics and Chemistry of Institute of Chemistry, Chinese Academy of Sciences have designed a new concept of hemostatic material from the perspective of hydrophilic and hydrophobic materials (gauze), which solves the problem of excessive blood absorption during the use of traditional gauze.They used nanotechnology to construct medical long-chain alkanes into micro-nano structure layers on the fiber surface of traditional gauze, transforming the conventional gauze from hemophilic to haemophobic, that is, blood cannot be infiltrated on the treated gauze surface.After that, they further superimposed the hemophilic gauze and the conventional gauze together, using the conventional gauze of the lower layer to promote blood coagulation, and using the hemophilic gauze of the upper layer to generate negative pressure to prevent blood soaking and penetration, so as to achieve the purpose of effective hemostasis and reducing blood loss.A large number of animal experiments show that compared with the traditional medical gauze, the new hemostatic gauze can significantly reduce the blood loss by about 60%.In addition, the use of the new hemostatic gauze can prolong the survival time of the mice in carotid artery bleeding by about 40%.The gauze is expected to buy patients more time to rescue.