ACS Nano 2019, 13, 13581-13594


         With an aging population, the market demand and research interest in arti implants have increased Recently, Professor Wu Shuilin’s group from the School of Materials Science and Engineering, Hubei University create a fast and repeatable photoelectric-responsive microenvironment around an implant using a bismuth sulfide/hydroxyapatite (BS/HAp) film. When BS is combined with HAp, the BS absorbs photons and then produces photoelectrons and electron-hole pairs. The photoelectrons are transferred to the phosphate in HAp, which decreases the combination of photogenerated electrons and holes. As a result, the photocatalytic capability of the BS/HAp film is enhanced and the photocurrent is increased. Furthermore, when the photogenerated electrons transfer to the membrane of MSCs, sodium-related gene expression changed. The concentration of sodium in intracellular and extracellular locations alters, resulting in a change in the membrane potential. This potential difference causes the Ca2+ inflow from the outside of the MSCs to the intracellular mitochondria. The increasing Ca2+ further upregulates FDE1 and ultimately enters the cell nucleus to regulate the TCF/LEF. Finally, DNA regulates the downstream genes related with osteogenic differentiation.