Adv. Funct. Mater. 2020, 2009258
Delayed wound healing has a profound impact on patients, health care and society. Growth factors (GFS) are multifunctional signaling molecules that coordinate a series of key events in wound healing. Since no single GF is the only determinant of wound healing efficiency, the strategy of combining multiple doses of commercial recombinant GFS has been used to achieve effective therapeutic effect. However, the high cost has set up a barrier for a wide range of clinical applications. Platelet rich plasma (PRP), as a blood derived product, is a concentrated platelet extracted from whole blood. It is an innovative tool in regenerative medicine and has been applied in clinic. The main challenge of PRP gel is still the decomposition and rapid elimination of GFS after the administration of protease in the wound environment. Its weak mechanical properties and the consequent blasting release effect limit its application and effect.
Recently, Professor Xu Fujian of Beijing University of Chemical Technology, associate professor Li Yang and Professor Hao Daifeng of General Hospital of PLA fourth Medical Center reported a kind of PRP based dual network hydrogel (DN gel) by simple one step activation process. Its improved gelling property and sustained release of growth factors may be beneficial for clinical use. Evaluations in rats indicate that DN gel promote wound healing in terms of rapid re-epithelialization, up-regulated growth factor levels and early transitions in the wound healing and angiogenesis stages. As a proof of concept, DN gel also exhibits superior healing efficiency in a porcine wound model. These results demonstrate the great potential of transforming this hydrogel into the next generation of PRP-based bioactive wound dressing.