Wang et al. / Biomaterials 171 (2018) 118—132





      Microcarrier is an injectable tissue engineering material with high flexibility. Microcarriers usually include polymer material microcarriers and natural material microcarriers. Among them, the natural material microcarriers are widely used because they are more suitable for the internal growth environment of the human body. However, microcarriers such as chitosan and collagen have low mechanical strength, fast degradation rate, and potential immunogenicity, which limits their applications in vivo. This article developed a chemical method to simulate the extracellular matrix (ECM) of nanofiber microcarriers for cartilage repair. The authors used sodium periodate to oxidize bacterial cellulose to obtain dialdehyde bacterial cellulose (DBC), and then combine hydroxyl The lysine (DHYL) through Schiff base reaction, finally forms a microcarrier structure through the Schiff base reaction and electrostatic adsorption with chitosan, and is implanted with bone marrow mesenchymal stem cells (BMSCs) under microgravity proliferation and differentiation in a rotating cell culture system (RCCS) to obtain chondrocyte microtissues. After mechanical evaluation, degradation experiments in vitro, immunofluorescence staining and other characteristics, it proves that the modified nanofiber microcarriers have good mechanical strength, slow degradation rate, and excellent cell activity. They are an advantageous material for cartilage repair, and the microstructure is more It is a potential target worth clinical research.

      Professor Zheng Yudong of Beijing University of Science and Technology graduated from Beijing University of Aeronautics and Astronautics with a bachelor’s and master’s degree; he obtained a Ph.D. in polymer materials from South China University of Technology. Worked in the School of Materials Science and Engineering of South China University of Technology from 1993 to 2004, mainly engaged in the research and development of biomaterials and functional polymer composites. In 2004, he worked in the Biomaterials Laboratory of the University of Science and Technology Beijing. In 2011 and 2013, he went to the UK for study visits and international project cooperation and exchanges. Mainly carried out the preparation and characterization of biomedical hydrogel implant materials, biocompatible conductive hydrogels, nano-biocomposites, and their applications in skin, cartilage, nerve repair and other medical fields.                                                            DOI: