Sci. Adv. 2020 Aug; eabb509


近日,爱尔兰都柏林三一生物医学科学研究所的Fiona E. Freeman教授提出了一种新的时空可控传递生长因子的方法。开发了一系列纳米颗粒功能化的生物墨水,以精确控制3D打印植入物中生长因子的时间释放。而不需要超生理剂量。具体地说,适当的血管内皮细胞生长因子促进了体内的血管生成,当与明确的BMP-2定位和释放动力学相结合时,可以促进大段骨缺损的愈合,而异位骨形成较少。


In recent years, many growth factors have been used in clinical trials for a variety of therapeutic applications, including bone regeneration and neovascularization of ischemic tissue. Although the early results are promising, the results obtained in larger phase II trials often do not show the expected benefits to patients, and some have significant side effects. Clinically, the current carrier of BMP-2 is collagen powder or sponge, which has been shown to cause a large number of initial burst release, which is in contrast to the expression profile observed during normal fracture repair. During normal fracture repair, the expression of BMP increased to the 21st day, indicating the need for slower and more sustained growth factor re-release spectrum. In addition, due to the short half-life of growth factors and harsh fracture environment, ultra-reasonable doses of BMP-2 are used to induce bone regeneration, which is related to adverse reactions such as ectopic ossification. Therefore, it is obviously necessary to develop a new strategy to transport single or multiple growth factors to the injured site with sustainable physiologically related doses, so as to induce repair without these adverse reactions.

Recently, Professor Fiona E. Freeman of the Trinity Institute of Biomedical Sciences in Dublin, Ireland, proposed a new method of spatio-temporal controllable transmission of growth factors. A series of nano-particle functionalized biological inks were developed to accurately control the time release of growth factors in 3D printing implants. Without the need for a super-physiological dose. Specifically, proper vascular endothelial growth factor can promote angiogenesis in vivo. When combined with clear BMP-2 localization and release kinetics, it can promote the healing of large bone defects, while ectopic bone formation is less.